Renal Emergency Medicine Neurology Strong — European consensus guidelines; EAN/ESE/ERA-EDTA endorsed
Sodium Correction Rate in Hyponatraemia
Calculates the volume of hypertonic saline (3% NaCl) or normal saline needed to correct hyponatraemia at a safe rate, preventing osmotic demyelination syndrome (ODS).
Used in: Hyponatraemia
Score interpretation
Expected Rise in Sodium per Litre of 3 % Saline (mmol/L) 0–100
Adrogué–Madias estimate; the actual rise varies, so recheck sodium frequently.
→ Keep correction within the local limit (commonly ≤ 10 mmol/L in the first 24 h; lower if at high risk of osmotic demyelination).
Interpretation bands for the Na⁺ Correction Rate. Apply clinical judgement and local guidance.
References
- Spasovski G, et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Eur J Endocrinol. 2014;170(3):G1–47.
- NICE guideline NG29. Intravenous fluid therapy in adults in hospital. 2013 (updated 2017).
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Drugs
- Sodium Chloride 3% (Hypertonic Saline) · Hypertonic Electrolyte Solution — ICP/Hyponatraemia Management
- Potassium chloride with calcium chloride and sodium chloride · Crystalloid IV fluid
- Potassium chloride with calcium chloride sodium chloride and sodium lactate · Balanced crystalloid IV fluid
- Potassium chloride with glucose and sodium chloride · IV fluid (mixed)
- Potassium chloride with sodium chloride · IV fluid (potassium + saline)
- Sodium chloride · Saline IV fluid / replacement
Pathways
- Hyperkalaemia Management · UK Kidney Association Guidelines 2020; NICE CKD Guidelines
- Rhabdomyolysis · Renal Association 2018; UpToDate 2024
- Hypocalcaemia (Adult) · Society for Endocrinology
- SIADH (Endocrine Perspective) · European Hyponatraemia Guidelines 2014
- Hepatorenal Syndrome · EASL 2018; ICA 2015
- Acute Kidney Injury (AKI) · KDIGO 2012 / NICE AKI 2019
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.