Emergency MedicineGeneral Medicine
Sepsis Screening and Sepsis Six
Identification of sepsis and immediate delivery of the Sepsis Six bundle within 1 hour of recognition.
Source: UK Sepsis Trust; NICE NG51; Surviving Sepsis Campaign 2021
Used in: Sepsis
Step 1 of ~8
question
Does This Patient Have Suspected Infection?
Screen for infection source: pneumonia, UTI, abdominal source, skin/soft tissue, line infection, other.
High-risk features — any ONE sufficient:
• NEWS ≥5 or NEWS rapidly rising
• Clinician concerned patient is acutely ill
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Morphine (Oral) · Strong Opioid Analgesic — Step 3 WHO Ladder
- Oxycodone · Strong Opioid Analgesic — Step 3 WHO Ladder
- Ceftriaxone (Paediatric) · Third-Generation Cephalosporin — Meningitis / Sepsis / Community-Acquired Pneumonia
- Gentamicin (Paediatric) · Aminoglycoside — Neonatal Sepsis / Gram-Negative Infections in Children
- Piperacillin-Tazobactam (Burns — Sepsis) · Antibiotic — Extended-Spectrum Penicillin + Beta-Lactamase Inhibitor
- Meropenem (Burns — Severe Sepsis/MDR) · Antibiotic — Carbapenem
Pathways
- Difficult Airway Algorithm (DAS) · DAS 2015; Royal College of Anaesthetists
- Major Haemorrhage Protocol · NICE NG24; UK MHP guidelines
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines
Featured in these MRCEM clinical pathways
A deeper exam-focused version of this pathway is available on our sister siteReviseMRCEM.
MRCEM Primary / Intermediate / OSCE candidates: each pathway includes exam-style questions, RCEM/NICE citations, and FAQ summaries.
Decision support only. Always apply local guidelines and clinical judgement.