Multiple Organ Dysfunction Score (MODS)
Quantifies the degree of dysfunction in 6 organ systems: respiratory, renal, hepatic, cardiovascular, haematological, and neurological. Predicts ICU mortality. Complements SOFA score.
Score interpretation
MODS 0–4: minimal organ dysfunction. ICU mortality 0–2 % (hospital mortality up to 7 %) in Marshall 1995.
→ Standard ICU care. Monitor for deterioration. Treat underlying cause.
MODS 5–8: moderate dysfunction. ICU mortality 3–5 % (hospital mortality 16 %) in Marshall 1995.
→ Goal-directed therapy. Optimise organ support. Daily reassessment. MDT approach.
MODS 9–12: severe dysfunction. ICU mortality ~25 % (hospital mortality ~50 %) in Marshall 1995.
→ Maximal organ support. ICU senior review. Prognosis discussion with family. Consider CRRT, vasopressors, mechanical ventilation as indicated.
MODS ≥ 13: critical multi-organ failure. ICU mortality ~50 % at 13–16, ~75 % at 17–20 and ~100 % above 20 (Marshall 1995).
→ Critical care escalation. Family meeting regarding prognosis. Treatment withdrawal assessment if clinically appropriate. Palliative care input if appropriate.
Interpretation bands for the MODS. Apply clinical judgement and local guidance.
References
- Marshall JC, et al. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med. 1995;23(10):1638-1652.
Related
Curated clinical cross-links plus same-class fallbacks.
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.
