Rai Staging System for CLL
Rai staging system for Chronic Lymphocytic Leukaemia (CLL) classifying disease into stages 0–IV based on lymphocytosis, organomegaly, and cytopenias.
Score interpretation
→ Rai Stage 0: lymphocytosis only. Median survival >150 months in Rai 1975 (historical). Watch and wait; no treatment needed unless iwCLL treatment criteria are met.
→ Rai Stage I: lymphocytosis with enlarged lymph nodes. Median survival 101 months in Rai 1975 (historical). Watch and wait unless symptomatic or iwCLL treatment criteria are met.
→ Rai Stage II: lymphocytosis with splenomegaly and/or hepatomegaly. Median survival 71 months in Rai 1975 (historical). Treat when symptomatic or iwCLL treatment criteria are met.
→ Rai Stage III: lymphocytosis with anaemia (Hb <11 g/dL). Median survival 19 months in Rai 1975 (historical). Treatment usually indicated — haematology referral.
→ Rai Stage IV: lymphocytosis with thrombocytopenia (platelets <100 ×10⁹/L). Median survival 19 months in Rai 1975 (historical). Treatment usually indicated — haematology referral.
Interpretation bands for the Rai CLL Staging. Apply clinical judgement and local guidance.
References
Related
Curated clinical cross-links plus same-class fallbacks.
- Fong Clinical Risk Score for Colorectal Cancer Recurrence · Oncology
- CRASH Score for Chemotherapy Risk Assessment in Elderly Patients · Oncology
- Ann Arbor Staging System for Lymphoma · Oncology
- Follicular Lymphoma International Prognostic Index (FLIPI) · Oncology
- International Staging System for Multiple Myeloma (ISS) · Oncology
- CISNE Score for Febrile Neutropenia · Oncology
- Omalizumab (Dermatology — Chronic Urticaria) · Anti-IgE Monoclonal Antibody
- Zoledronic Acid · Bisphosphonate (IV)
- Denosumab · RANK Ligand Inhibitor (Anti-resorptive)
- Zoledronic Acid · IV Bisphosphonate
- Fentanyl Transdermal Patch (Elderly Chronic Pain) · Opioid Analgesic — Transdermal Patch
- Morphine Slow-Release (Elderly Chronic Pain) · Opioid Analgesic — Modified-Release Oral
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.
