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Thiazide-like diuretic

Indapamide

Brand names: Natrilix

Used in: Hypertension

Indapamide is a thiazide-like diuretic used for hypertension.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

US labelling (FDA)

Reference — US labelling, may differ from UK

DOSAGE & ADMINISTRATION Hypertension : The adult starting indapamide dose for hypertension is 1.25 mg as a single daily dose taken in the morning. If the response to 1.25 mg is not satisfactory after 4 weeks, the daily dose may be increased to 2.5 mg taken once daily. If the response to 2.5 mg is not satisfactory after 4 weeks, the daily dose may be increased to 5.0 mg taken once daily, but adding another antihypertensive should be considered. Edema of Congestive Heart Failure : The adult starting indapamide dose for edema of congestive heart failure is 2.5 mg as a single daily dose taken in the morning. If the response to 2.5 mg is not satisfactory after one week, the daily dose may be …

Source: US FDA prescribing information (openFDA / DailyMed), label dated 2023-06-26. Accessed 2026-06-12. US dosing and indications can differ from UK practice — use UK sources for prescribing decisions.

Clinical monograph

How it works

It acts on the distal tubule to reduce sodium reabsorption, with additional vasodilatory effects, lowering blood pressure.

Prescribing in practice

  • It can cause hyponatraemia and hypokalaemia — check electrolytes after starting and periodically.
  • It is the preferred type of thiazide-like diuretic in current UK hypertension guidance.
  • Use caution in gout (it can raise urate) and review glucose and lipids over time.

Monitoring

Check U&E (sodium, potassium, renal function) after initiation and periodically; monitor blood pressure.

Counselling the patient

  • Report marked tiredness, cramps, dizziness or confusion (possible low salt or potassium).
  • Take it in the morning to avoid night-time urination.

Evidence & guidelines

A thiazide-like diuretic recommended for hypertension in NICE NG136, preferred over conventional thiazides.

Reference: NICE NG136; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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