Androgen (Male Sex Hormone)

Testosterone (Replacement)

Brand names: Testogel, Nebido (IM), Testim gel, Tostran gel

Testosterone replacement is used for confirmed male hypogonadism only. It is not appropriate for age-related symptoms in the absence of biochemical hypogonadism.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It replaces endogenous testosterone, acting on androgen receptors to restore male secondary sexual characteristics and physiological androgen effects.

Prescribing in practice

Confirm low morning testosterone on more than one occasion before starting; it is contraindicated in prostate or male breast cancer.
Monitor haematocrit because of the risk of polycythaemia.
Assess prostate status and PSA before and during treatment.

Monitoring

Monitor testosterone levels, haematocrit and prostate health (including PSA), with clinical review of response and adverse effects.

Counselling the patient

This treatment is for a diagnosed testosterone deficiency, not for normal ageing.
Attend for blood tests to check your red cell count and prostate marker.
Report difficulty passing urine or other prostate symptoms.

Evidence & guidelines

Indicated for biochemically confirmed male hypogonadism per the SPC and specialist guidance.

Reference: European Association of Urology (EAU) Guidelines on Male Hypogonadism 2022; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Curated clinical cross-links plus same-class fallbacks.

Calculators

Pathways