Emergency Medicine Toxicology Strong — MHRA and NPIS recommended treatment threshold
Rumack-Matthew Nomogram
Determines need for N-acetylcysteine (NAC) treatment following paracetamol (acetaminophen) overdose based on serum level and time post-ingestion
References
- Rumack BH, Matthew H. Acetaminophen poisoning and toxicity. Pediatrics. 1975;55(6):871–876.
- TOXBASE / NPIS. Paracetamol Overdose Treatment Guidelines. 2023.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Drugs
- Acetylcysteine (N-acetylcysteine — Paracetamol Overdose) · Mucolytic / Hepatoprotective Antidote
- Acetylcysteine (N-acetylcysteine — NAC) · Antidote — paracetamol overdose / Hepatoprotectant
- Acetylcysteine · Mucolytic / Paracetamol overdose antidote
- Dobutamine (Acute HF / Stress Echo) · Inotrope / Acute Heart Failure
- Milrinone · Inodilator / Acute Heart Failure
- Vericiguat · Heart Failure
Pathways
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines
- Syncope Assessment · ESC 2018 Syncope Guidelines; NICE NG109
- Acute Chest Pain · NICE CG95; ESC 2023 ACS Guidelines
Decision support only — verify against MDCalc, NICE, or your local guideline before clinical use.