Modified Glasgow Prognostic Score (mGPS)
Modified version of GPS that only scores high CRP (>10 mg/L) with hypoalbuminaemia (<35 g/L) together as the worst prognostic category. Used widely in surgical oncology.
Score interpretation
No systemic inflammation. Best prognosis category.
→ Standard oncological management
Elevated CRP without hypoalbuminaemia. Intermediate prognosis.
→ Monitor nutritional status; optimise pre-operative nutrition if surgical candidate
Elevated CRP with hypoalbuminaemia. Worst prognosis. Associated with reduced survival and treatment tolerance.
→ Early palliative care referral; nutritional supplementation; consider fitness for aggressive treatment
Interpretation bands for the mGPS. Apply clinical judgement and local guidance.
References
- Forrest LM et al. Comparison of an inflammation-based prognostic score (GPS) with performance status (ECOG) in patients receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer. Br J Cancer. 2004;90(9):1704–1706.
Related
Curated clinical cross-links plus same-class fallbacks.
- Fong Clinical Risk Score for CRC Liver Metastases · Cancer Prognosis
- FLIPI — Follicular Lymphoma International Prognostic Index · Cancer Prognosis
- CLL-IPI (International Prognostic Index for CLL) · Cancer Prognosis
- DIPSS — Dynamic International Prognostic Scoring System for Myelofibrosis · Cancer Prognosis
- IMDC Risk Model for Metastatic Renal Cell Carcinoma · Cancer Prognosis
- WPSS — WHO Prognostic Scoring System for MDS · Cancer Prognosis
- Colchicine (Pericarditis / Post-MI Inflammation) · Pericarditis / Coronary Inflammation
- Hydrocortisone (Oral Replacement) · Glucocorticoid Replacement
- Cetuximab · Anti-EGFR Monoclonal Antibody — Head and Neck Cancer
- Cisplatin · Platinum Chemotherapy — Head and Neck Cancer
- Dexamethasone · Corticosteroid — ENT Inflammation / Croup
- Morphine (Oral) · Strong Opioid Analgesic — Step 3 WHO Ladder
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.