Metaraminol
Brand names: Aramine
Metaraminol is a sympathomimetic vasopressor used to treat acute hypotension, particularly that arising during anaesthesia.
ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.
Clinical monograph
How it works
It acts predominantly as an alpha-1 adrenoceptor agonist causing vasoconstriction, and also has an indirect action through release of noradrenaline from sympathetic nerve terminals.
Prescribing in practice
- It can cause severe hypertension and reflex bradycardia, so it should be titrated carefully with close blood pressure monitoring.
- Extravasation can cause tissue ischaemia and necrosis; ideally administer through a secure, well-running cannula or central line.
- Use with caution in patients on monoamine oxidase inhibitors or with significant cardiovascular disease.
Monitoring
Monitor blood pressure and heart rate frequently, and inspect the infusion site for signs of extravasation.
Counselling the patient
- This medicine is given by the clinical team to support blood pressure and is monitored closely.
- Report any pain, burning, or swelling at the drip site immediately.
Evidence & guidelines
Use reflects established perioperative practice for managing hypotension; consult current prescribing references and the SPC.
Reference: AAGBI Guidelines; RCoA Regional Anaesthesia Guidelines; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).
Related
Curated clinical cross-links plus same-class fallbacks.