Sufentanil

How it works

It is a highly potent selective mu-opioid receptor agonist, producing profound analgesia and dose-dependent central nervous system depression.

Prescribing in practice

• Owing to its high potency it causes profound dose-dependent respiratory depression and must be used only where airway management and ventilatory support are immediately available.
• Effects, including respiratory depression, are potentiated by other central nervous system depressants and can outlast a single opioid antagonist dose, requiring continued observation.
• It can cause bradycardia, hypotension and muscle rigidity, particularly with rapid administration.

Monitoring

Continuous monitoring of respiration, oxygenation and haemodynamics is required during and after administration.

Counselling the patient

• This is a very potent opioid given by trained anaesthetic staff with close monitoring.
• Drowsiness and slowed breathing can occur and are watched for closely.

Evidence & guidelines

Its high potency and use as an opioid analgesic in anaesthesia are well established and described in the SPC.