Fibrate / PPAR-α agonist
Ciprofibrate
Brand names: Modalim
Adult dose
Dose: 100mg OD
Route: PO
Frequency: OD
Clinical pearls
- Used for severe hypertriglyceridaemia not responding to lifestyle/statin
- Check CK before starting and if symptoms
Contraindications
- Severe renal impairment (CrCl <60)
- Hepatic impairment
- Gallbladder disease
- Pregnancy/breastfeeding
Side effects
- Myopathy / rhabdomyolysis
- GI upset
- Headache
- Cholelithiasis
- Erectile dysfunction
Interactions
- Statins — myopathy risk (avoid combination if possible)
- Warfarin — INR rise
- Ciclosporin — renal toxicity
Monitoring
- LFTs
- Lipids
- CK if symptoms
- U&E
Reference: BNF; NICE CG181; https://bnf.nice.org.uk/drugs/ciprofibrate/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Acute Heart Failure · ESC 2021 Heart Failure Guidelines; NICE NG106
- NSTEMI / Unstable Angina · ESC 2020 NSTEMI Guidelines; NICE NG185
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines