Atenolol + chlortalidone
Co-tenidone
Brand names: Tenoretic
Adult dose
Dose: 50mg/12.5mg or 100mg/25mg OD
Route: PO
Frequency: OD
Clinical pearls
- Hypertension fixed-combination — newer agents preferred per NICE NG136
Contraindications
- Asthma
- Severe bradycardia
- Severe heart failure
- Cardiogenic shock
- Sick sinus
- 2nd/3rd degree AV block
- Severe renal impairment
Side effects
- Bradycardia
- Cold extremities
- Fatigue
- Hypokalaemia
- Hyperuricaemia
- Hyperglycaemia
- Erectile dysfunction
Interactions
- Verapamil/diltiazem (severe bradycardia)
- NSAIDs (reduce diuretic)
- Lithium toxicity
Monitoring
- BP
- HR
- U&E
- Glucose
Reference: BNF; https://bnf.nice.org.uk/drugs/co-tenidone/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Acute Heart Failure · ESC 2021 Heart Failure Guidelines; NICE NG106
- NSTEMI / Unstable Angina · ESC 2020 NSTEMI Guidelines; NICE NG185
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines