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ARB + thiazide

Valsartan with hydrochlorothiazide

Brand names: Co-Diovan

Adult dose

Dose: 80/12.5mg, 160/12.5mg, 160/25mg or 320/25mg PO OD
Route: PO
Frequency: OD

Clinical pearls

  • Hypertension when monotherapy inadequate
  • Monitor electrolytes

Contraindications

  • Pregnancy
  • Severe renal/hepatic impairment
  • Anuria
  • Refractory hypokalaemia
  • Symptomatic hyperuricaemia

Side effects

  • Hypokalaemia
  • Hyponatraemia
  • Hyperuricaemia
  • Hypotension
  • Glucose intolerance

Interactions

  • NSAIDs
  • Lithium
  • Other antihypertensives

Monitoring

  • U&E
  • BP
  • Glucose

Reference: BNF; NICE NG136; https://bnf.nice.org.uk/drugs/valsartan-with-hydrochlorothiazide/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.