Topical antibiotic + BPO (acne)
Benzoyl peroxide with clindamycin
Brand names: Duac, Acnecide
Adult dose
Dose: Apply OD in evening
Route: Topical
Frequency: OD
Clinical pearls
- NICE NG198 acne: 1st-line moderate acne — combines benzoyl peroxide (limits resistance) with clindamycin
- BAD acne guideline
- Duration limited to 12 weeks per BPO + antibiotic course
Contraindications
- IBD history
- Hypersensitivity
Side effects
- Local irritation, dryness, peeling
- Photosensitivity
- Bleaching of fabric
- C. difficile (rare with topical)
Interactions
- Topical retinoids (combine but separate timing)
- Sun exposure
Monitoring
- Treatment response at 12 weeks
- Local tolerance
Reference: BNF; NICE NG198; BAD; https://bnf.nice.org.uk/drugs/benzoyl-peroxide-with-clindamycin/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Acne Severity Classification (IGA Scale) · Acne
- Centor / McIsaac Score for Strep Pharyngitis · Throat
- FeverPAIN Score for Strep Throat · Throat
- Jarisch-Herxheimer Reaction Severity Assessment · Treatment Reactions
- PID Severity (CDC Diagnostic Criteria) · Gynaecological Infections
- FAST Exam Protocol — Focused Assessment with Sonography in Trauma · Trauma
Pathways
- Suspicious Pigmented Lesion — Melanoma Pathway · NICE NG14 2015 / BAD
- Cellulitis and Erysipelas · NICE NG141 2019 / CREST
- Psoriasis — Severity Assessment and Step-Up Therapy · NICE NG153 2019 / BAD
- Atopic Eczema — Assessment and Step-Up Therapy · NICE NG95 2023
- Urticaria and Angioedema · BSACI / EAACI Guidelines 2022
- Acne Vulgaris — Grading and Treatment · NICE NG198 2021 / BAD