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Topical Antiparasitic — Rosacea

Ivermectin Cream (Topical)

Brand names: Soolantra

Topical ivermectin cream is an antiparasitic and anti-inflammatory agent applied to the face for the inflammatory papulopustular lesions of rosacea.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It has both anti-inflammatory effects and acaricidal activity against Demodex mites, which are implicated in the pathogenesis of papulopustular rosacea.

Prescribing in practice

  • For external cutaneous use only; avoid contact with the eyes, lips and mucous membranes, and wash hands after application.
  • Apply a thin layer once daily to the affected areas of the face, avoiding broken or irritated skin.
  • Transient local effects such as burning, skin irritation, pruritus or dryness may occur early in treatment.

Monitoring

Monitoring is clinical, reviewing the response of inflammatory lesions and any local skin reactions, with reassessment if no improvement is seen after an adequate trial.

Counselling the patient

  • Apply once daily and continue as directed even if improvement is gradual.
  • Use only on the face and keep it away from the eyes, lips and inside the nose.
  • Mild stinging or dryness can occur at first and usually settles.

Evidence & guidelines

Topical ivermectin is an established treatment option for papulopustular rosacea and is supported by NICE clinical guidance on rosacea management.

Reference: ATTRACT Trial (Taieb et al. Br J Dermatol 2015); BAD Rosacea Guidelines 2017; NICE CKS Rosacea; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

Pathways