Tazarotene

How it works

As a receptor-selective retinoid it binds retinoic acid receptors to normalise keratinocyte differentiation and proliferation and exert anti-inflammatory effects in the skin.

Prescribing in practice

• Contraindicated in pregnancy and in women planning pregnancy because of the teratogenic potential of retinoids, so effective contraception is required.
• Apply sparingly to plaques only, avoiding healthy skin, flexures, the face and eyes to limit irritation.
• Skin irritation is dose-related and patients should minimise sun exposure and use sun protection.

Monitoring

No routine bloods are required; monitor for local irritation and review treatment response, and confirm pregnancy status where relevant.

Counselling the patient

• Do not use if pregnant, breastfeeding or trying to conceive, and use reliable contraception.
• Apply a thin layer to the plaques only and protect surrounding skin.
• Redness, burning and dryness are common, especially early in treatment, and sun protection should be used.

Evidence & guidelines

Topical tazarotene is an established option for localised plaque psoriasis and acne, supported by randomised controlled trial evidence.