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PTHrP analogue (anabolic)

Abaloparatide

Brand names: Eladynos

Adult dose

Dose: 80 micrograms

Route: Subcutaneous

Frequency: Once daily for max 18 months

Clinical pearls

For postmenopausal osteoporosis at high fracture risk
Follow with antiresorptive on completion

Contraindications

Pre-existing hypercalcaemia
Severe renal impairment
Prior skeletal radiotherapy
Bone metastases
Paget disease

Side effects

Hypercalcaemia
Palpitations
Dizziness
Nausea
Injection site reaction

Interactions

Cardiac glycosides (monitor)
Loop diuretics

Monitoring

Serum and urinary calcium
BMD
BP/HR

Reference: BNF; NICE TA991; SmPC Eladynos. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

Pathways