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Calcitonin analogue

Calcitonin (salmon)

Brand names: Miacalcic

Adult dose

Dose: Hypercalcaemia of malignancy: 100 units IM/SC q6–8h; Paget's: 50–100 units OD/3× weekly
Route: SC / IM (intranasal withdrawn)
Frequency: q6–8h or 3× weekly

Clinical pearls

  • MHRA Drug Safety Update 2012: long-term use restricted due to malignancy signal — only for short-term treatment of hypercalcaemia of malignancy and Paget's disease; intranasal withdrawn
  • Bisphosphonates / denosumab generally preferred for hypercalcaemia

Contraindications

  • Hypocalcaemia
  • Hypersensitivity

Side effects

  • Nausea
  • Flushing
  • Local reactions
  • Allergic reactions
  • Increased malignancy risk with long-term use (MHRA — restricted indications)

Interactions

  • Lithium

Monitoring

  • Calcium
  • Symptoms
  • Duration of use

Reference: BNF; MHRA Drug Safety Update; SmPC; https://bnf.nice.org.uk/drugs/calcitonin-salmon/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.