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SGLT2 inhibitor

Ertugliflozin

Brand names: Steglatro

Adult dose

Dose: 5mg OD (max 15mg OD)
Route: Oral
Frequency: OD

Clinical pearls

  • NICE NG28: SGLT2i class option; empagliflozin and dapagliflozin have stronger CV/renal outcome evidence
  • ADA-EASD and ESC HF: SGLT2i for HF and CKD reduction
  • MHRA DKA / volume depletion warnings

Contraindications

  • Type 1 diabetes
  • DKA history
  • Severe renal impairment
  • Pregnancy
  • Hypersensitivity

Side effects

  • Genitourinary infections
  • Volume depletion
  • DKA (atypical)
  • Fournier's gangrene
  • Lower-limb amputation signal (less robust than canagliflozin)

Interactions

  • Diuretics
  • RAAS inhibitors
  • Insulin/sulfonylureas (hypoglycaemia)

Monitoring

  • HbA1c
  • eGFR
  • Volume status
  • Foot care
  • Sick-day rules

Reference: BNF; NICE NG28; MHRA Drug Safety Update; ADA-EASD consensus; https://bnf.nice.org.uk/drugs/ertugliflozin/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.