Recombinant human TSH
Thyrotropin alfa
Brand names: Thyrogen
Adult dose
Dose: 0.9mg IM OD x2 doses (24h apart) — for Tg testing or radioiodine ablation
Route: IM
Frequency: x2 doses
Clinical pearls
- Avoids hypothyroid period for thyroglobulin / radioiodine in differentiated thyroid cancer follow-up
- Specialist endocrine
Contraindications
- Hypersensitivity
- Pregnancy/breastfeeding
Side effects
- Nausea
- Headache
- Asthenia
- Tumour swelling
- Hypersensitivity
Monitoring
- Tg
- TSH
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/thyrotropin-alfa/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Diabetic Ketoacidosis (DKA) · JBDS 2013 / Joint British Diabetes Societies; NICE NG17
- Adult Hypoglycaemia (Treated Diabetes) · JBDS-IP (2023): Hospital Management of Hypoglycaemia
- Adrenal Crisis · Society for Endocrinology Emergency Guidance (2024)
- Type 2 Diabetes Management · NICE NG28 2022
- Hyperthyroidism Management · BTA / ETA 2018
- Adrenal Insufficiency · Society of Endocrinology / ESE 2016