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GnRH analogue (decapeptide)

Triptorelin

Brand names: Decapeptyl SR, Gonapeptyl

Adult dose

Dose: Prostate: 3.75mg IM monthly or 11.25mg every 3 months. Endometriosis: 3.75mg IM monthly. Precocious puberty: weight-based (specialist)

Route: IM/SC

Frequency: monthly or 3-monthly

Clinical pearls

Advanced prostate cancer (with antiandrogen for first 2-3 weeks); endometriosis; precocious puberty
Add-back HRT for prolonged use in benign indications

Contraindications

Pregnancy
Severe hepatic impairment
Hypersensitivity

Side effects

Tumour flare initially
Hot flushes
Erectile dysfunction
Reduced BMD
Cardiovascular events
Mood changes
Hyperglycaemia

Interactions

QT-prolonging drugs (caution)
Hormonal therapies

Monitoring

Testosterone/PSA
BMD
BP

Reference: BNF; NICE NG131; https://bnf.nice.org.uk/drugs/triptorelin/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

Pathways