Bee venom extracts

How it works

Repeated controlled administration of the venom allergen induces immune tolerance, shifting the allergic response and reducing the risk of severe systemic reactions on subsequent stings.

Prescribing in practice

• Administration carries a risk of anaphylaxis and must take place only in a specialist setting with full resuscitation facilities and trained staff immediately available.
• Confirm genuine venom allergy with appropriate diagnostic testing before starting, as immunotherapy is reserved for sensitised individuals with significant reactions.
• Concurrent beta-blocker or ACE inhibitor therapy may worsen or complicate the treatment of any anaphylactic reaction and should be reviewed.

Monitoring

Observe the patient for an appropriate period after each dose for systemic and local allergic reactions, with anaphylaxis management available throughout.

Counselling the patient

• This treatment gradually builds up your tolerance to bee stings.
• You will be observed after each dose because of the risk of an allergic reaction.
• Carry your prescribed adrenaline auto-injector and seek emergency help if you have a severe reaction.

Evidence & guidelines

Venom immunotherapy is established as effective for reducing the risk of severe systemic sting reactions in confirmed venom-allergic patients.