B-vitamin combination

Vitamin B complex

Brand names: Vigantol B-Co

Vitamin B complex preparations combine several water-soluble B vitamins (such as thiamine, riboflavin, niacin, pyridoxine and others) used to prevent or treat deficiency states.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

The constituent B vitamins act as essential coenzymes in carbohydrate, protein and fat metabolism and in energy production and nerve function.

Prescribing in practice

Confirm the specific deficiency and choose an appropriate formulation, as high-dose pyridoxine taken chronically can cause peripheral neuropathy.
Water-soluble vitamins are generally well tolerated and excess is largely excreted renally, but the individual constituents should be checked against the indication.
In suspected Wernicke's encephalopathy, parenteral thiamine-containing high-potency preparations are required rather than a standard oral B complex.

Monitoring

Monitoring is primarily clinical, assessing resolution of deficiency symptoms, with biochemical testing reserved for specific deficiencies.

Counselling the patient

Take as directed and do not exceed the recommended intake.
Some products may colour the urine bright yellow, which is harmless.

Evidence & guidelines

B vitamin replacement for deficiency is well established in clinical practice and reflected in UK prescribing references.

Reference: Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Curated clinical cross-links plus same-class fallbacks.

Calculators

Pathways