Carbapenem + β-lactamase inhibitor
Imipenem with cilastatin and relebactam
Brand names: Recarbrio
Adult dose
Dose: 1.25g IV every 6h (refer to BNF for renal dose)
Route: IV
Frequency: q6h
Dose adjustments
Renal
Mandatory — refer to BNF
Clinical pearls
- Activity against KPC-producing carbapenem-resistant Enterobacterales; specialist micro/ID input
Contraindications
- Hypersensitivity
Side effects
- As imipenem
- Diarrhoea
- Hepatotoxicity
Interactions
- Valproate (avoid)
- Other carbapenem interactions
Monitoring
- U&E
- LFTs
- FBC
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/imipenem-with-cilastatin-and-relebactam/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- SMART Risk Score for Recurrent CVD · Cardiovascular Risk
- PCSK9 Inhibitor Eligibility Assessment · Lipid Management
- Immune-Related Adverse Events (irAE) -- GI Toxicity Colitis Grading · Oncology-Related GI
- irAE Hepatitis Grading (CTCAE) · Immunotherapy
- DIPSS — Dynamic International Prognostic Scoring System for Myelofibrosis · Cancer Prognosis
- BALL Score for Relapsed/Refractory CLL · Leukaemia