Continuous SC levodopa/carbidopa
Foslevodopa with foscarbidopa
Brand names: Vyalev, Produodopa
Adult dose
Dose: Continuous 24h SC infusion via pump; titrate per individual oral levodopa equivalent
Route: SC infusion
Frequency: continuous
Clinical pearls
- Advanced Parkinson's with persistent motor fluctuations on optimised oral therapy
- Specialist movement-disorder clinic
Contraindications
- Closed-angle glaucoma
- Severe psychiatric disease
- Concurrent non-selective MAOI
Side effects
- Infusion site reactions (common)
- Dyskinesias
- Hallucinations
- Postural hypotension
- On-off phenomena
- Impulse control disorders
Interactions
- MAOIs
- Antipsychotics (antagonism)
Monitoring
- Motor symptoms
- BP
- Mental state
- Skin sites
Reference: BNF; NICE NG71; SmPC; https://bnf.nice.org.uk/drugs/foslevodopa-with-foscarbidopa/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Pathways
- Acute Stroke / TIA Assessment · NICE NG128; RCP Stroke Guidelines 2023
- Status Epilepticus (Adults) · NICE CG137; ESEM guidelines; RCP Neurology Guidelines
- Suspected Subarachnoid Haemorrhage · NICE NG228; RCEM 2023; AHA/ASA 2023
- Adult Head Injury · NICE NG232 (2023)
- Bell's Palsy / Facial Nerve Palsy · ENT UK 2017; AAN
- Vertigo Workup · ENT UK; NICE CKS