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Triazole-derivative antiepileptic

Rufinamide

Brand names: Inovelon

Adult dose

Dose: Initial 400mg PO BD (with food), increase by 400mg/day every 2 days; max 3.2g/day

Route: PO

Frequency: BD

Clinical pearls

Lennox-Gastaut syndrome (≥1 year) as adjunct
Take with food

Contraindications

Familial short QT syndrome
Severe hepatic impairment
Hypersensitivity

Side effects

Drowsiness
Headache
Dizziness
Shortened QT interval
Hypersensitivity syndrome (DRESS)
Suicidal ideation

Interactions

Valproate (raises rufinamide)
Carbamazepine/phenytoin (lower)
Hormonal contraceptives (reduces efficacy)

Monitoring

ECG
Symptoms
Mood

Reference: BNF; NICE NG217; https://bnf.nice.org.uk/drugs/rufinamide/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

Pathways