Antiepileptic (orphan)
Stiripentol
Brand names: Diacomit
Adult dose
Dose: 50 mg/kg/day PO in 2-3 divided doses (with clobazam ± valproate)
Route: PO
Frequency: divided
Clinical pearls
- Dravet syndrome (SCN1A) refractory generalised tonic-clonic seizures — orphan
- Specialist neurology
Contraindications
- Severe hepatic impairment
- Severe renal impairment
- Hypersensitivity
Side effects
- Sedation
- Anorexia
- Weight loss
- Ataxia
- Cytopenias
- Hepatic enzyme elevation
Interactions
- Strong CYP inhibitor — many
- Clobazam (raises norclobazam — usually intentional)
- Valproate
Monitoring
- FBC
- LFTs
- Drug levels (concomitant)
Reference: BNF; NICE; SmPC; https://bnf.nice.org.uk/drugs/stiripentol/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Acute Stroke / TIA Assessment · NICE NG128; RCP Stroke Guidelines 2023
- Status Epilepticus (Adults) · NICE CG137; ESEM guidelines; RCP Neurology Guidelines
- Suspected Subarachnoid Haemorrhage · NICE NG228; RCEM 2023; AHA/ASA 2023
- Adult Head Injury · NICE NG232 (2023)
- Bell's Palsy / Facial Nerve Palsy · ENT UK 2017; AAN
- Vertigo Workup · ENT UK; NICE CKS