Triptan + NSAID combination
Sumatriptan with naproxen
Adult dose
Dose: 85/500mg PO at onset, may repeat after 2h (max 2 tabs/24h)
Route: PO
Frequency: PRN
Clinical pearls
- Combination acute migraine — superior to monotherapy
- Limited UK availability; can be co-prescribed separately
Contraindications
- IHD/CVD
- Active GI ulcer
- Severe HF
- Severe renal/hepatic impairment
- Pregnancy (3rd trimester)
- NSAID-induced asthma
- Concurrent ergotamine / triptan / MAOI within 14 days
Side effects
- Chest tightness
- Paraesthesia
- GI bleeding
- Renal impairment
- Coronary vasospasm
Interactions
- MAOIs
- Other triptans/ergot
- SSRIs/SNRIs
- NSAIDs (additive)
- Anticoagulants
Monitoring
- Symptoms
- BP
- U&E
Reference: BNF; NICE CG150; https://bnf.nice.org.uk/drugs/sumatriptan-with-naproxen/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Pathways
- Acute Stroke / TIA Assessment · NICE NG128; RCP Stroke Guidelines 2023
- Status Epilepticus (Adults) · NICE CG137; ESEM guidelines; RCP Neurology Guidelines
- Suspected Subarachnoid Haemorrhage · NICE NG228; RCEM 2023; AHA/ASA 2023
- Adult Head Injury · NICE NG232 (2023)
- Bell's Palsy / Facial Nerve Palsy · ENT UK 2017; AAN
- Vertigo Workup · ENT UK; NICE CKS