Natural progestogen (micronised)
Progesterone
Brand names: Cyclogest, Crinone, Utrogestan, Lutigest
Adult dose
Dose: HRT (combined): 100mg PO OD continuous or 200mg ON for 12 days/cycle. Threatened miscarriage: 400mg vaginal BD. Luteal support (IVF): 400mg vaginal BD
Route: PO/Vaginal/Rectal
Frequency: per indication
Clinical pearls
- Body-identical progesterone — preferred for HRT (lower VTE/breast risk than synthetic)
- Threatened miscarriage with previous loss (PRISM trial / NICE NG126)
Contraindications
- Undiagnosed vaginal bleeding
- Severe hepatic impairment
- Active VTE
- Hormone-dependent cancer
Side effects
- Drowsiness (PO)
- Headache
- Breast tenderness
- Mood changes
- Vaginal discharge
Interactions
- Strong CYP3A4 modulators
- Hormonal therapies
Reference: BNF; NICE NG23/NG126; https://bnf.nice.org.uk/drugs/progesterone/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.