Combined vaccine (dTaP/Tdap)
Diphtheria with tetanus and pertussis vaccine
Brand names: Boostrix-IPV (without polio), various dTaP/Tdap
Adult dose
Dose: 0.5mL IM per UK schedule (3-in-1 booster age 14)
Route: IM
Frequency: Per schedule
Clinical pearls
- UKHSA Green Book chapters 14, 24, 30
- UK national immunisation schedule — pertussis-containing vaccine in pregnancy (Boostrix-IPV) at 16+ weeks for neonatal protection
Contraindications
- Severe hypersensitivity to vaccine components
- Encephalopathy within 7 days of prior pertussis-containing vaccine
Side effects
- Local injection-site reaction
- Fever
- Irritability
- Drowsiness
- Anaphylaxis (rare)
Interactions
- Immunosuppressives (reduced response)
Monitoring
- Post-vaccination observation 15 min
- Yellow Card AE reporting
Reference: BNF; UKHSA Green Book; NHS England immunisation schedule; https://bnf.nice.org.uk/drugs/diphtheria-with-tetanus-and-pertussis-vaccine/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.