Topical Antimicrobial Dressing
Pregnancy: C
Mafenide Acetate / Framycetin
Brand names: Sofra-Tulle (framycetin), Jelonet
Adult dose
Dose: Apply single layer to wound; change every 1–3 days depending on exudate
Route: topical dressing
Frequency: every 1–3 days
Max: Cover wound surface only
Jelonet (paraffin gauze): simple non-adherent dressing; Sofra-Tulle (framycetin): for lightly infected burns; change frequency depends on exudate level and wound condition
Paediatric dose
Route: topical
Frequency: every 1–3 days
Concentration: Sofra-Tulle: 1% framycetin sulfate impregnated tulle gras /ml
Safe for all ages topically; monitor for sensitisation (neomycin/framycetin allergy — common)
Dose adjustments
Renal
Not applicable
Hepatic
Not applicable
Clinical pearls
- Jelonet: gold standard donor site dressing — painless removal after epithelialisation
- Sofra-Tulle: limited to 10 days maximum — prevents sensitisation to framycetin
- Paraffin gauze advantage: non-adherent, prevents mechanical trauma at dressing change — reduces pain and protects new epithelium
Contraindications
- Known aminoglycoside hypersensitivity (framycetin)
Side effects
- Contact sensitisation (framycetin — neomycin cross-reactivity)
- Local irritation
Interactions
- None significant
Monitoring
- Wound healing
- Signs of sensitisation
Reference: BNFc; BNF 86; BBA dressings guidelines. Verify against your local formulary and the latest BNF before prescribing.