Phosphate binder
Lanthanum carbonate
Brand names: Fosrenol
Adult dose
Dose: 750mg–3g/day with meals
Route: PO
Frequency: with meals
Clinical pearls
- Hyperphosphataemia in CKD
- Chew tablets thoroughly with meals
Contraindications
- GI obstruction
Side effects
- GI upset (nausea/vomiting/abdominal pain)
- Hypocalcaemia
- Lanthanum deposition (chronic — long-term concerns)
Interactions
- Tetracyclines/quinolones (chelation; separate by 2h)
- Levothyroxine
- Antacids
Monitoring
- Phosphate
- Calcium
- PTH
Reference: BNF; NICE NG203; https://bnf.nice.org.uk/drugs/lanthanum/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.