CFTR modulator triple

Ivacaftor with tezacaftor and elexacaftor

Brand names: Kaftrio (with Kalydeco)

Adult dose

Dose: 2 tablets (elexacaftor 100mg/tezacaftor 50mg/ivacaftor 75mg) in morning + ivacaftor 150mg in evening; with fat-containing food

Route: PO

Frequency: BD

Clinical pearls

Cystic fibrosis with at least one F508del mutation; transformative outcome data
Specialist CF centre prescribing

Contraindications

Severe hepatic impairment without dose adjustment

Side effects

Headache
Diarrhoea
Rash
Hepatotoxicity
Cataract (paediatric)
Mental health changes (depression, anxiety — rare)

Interactions

Strong CYP3A4 modulators
Hormonal contraceptives (interaction reported)
Warfarin

Monitoring

LFTs
Ophthalmic (children)
Mental health

Reference: BNF; NICE TA787; SmPC; https://bnf.nice.org.uk/drugs/ivacaftor-with-tezacaftor-and-elexacaftor/. Verify against your local formulary and the latest BNF before prescribing.

Curated clinical cross-links plus same-class fallbacks.

Calculators

FAST Exam Protocol — Focused Assessment with Sonography in Trauma · Trauma

Pathways