Short-acting SSRI (premature ejaculation)

Dapoxetine

Brand names: Priligy

Adult dose

Dose: 30mg 1–3h before sexual activity (max 60mg); not more than once daily

Route: Oral

Frequency: PRN; max OD

Clinical pearls

NICE / BAUS premature ejaculation guidance
Only SSRI licensed for on-demand PE
Counsel about syncope risk — sit/lie down if dizzy

Contraindications

Significant cardiac disease
History of mania / severe depression
MAOI within 14 days
Concurrent strong CYP3A4 inhibitors
Severe hepatic impairment
Hypersensitivity

Side effects

Nausea
Dizziness
Headache
Syncope (orthostatic — counsel hydration)
Anxiety
Insomnia
Hypomania (rare)

Interactions

MAOIs / serotonergics (serotonin syndrome)
Strong CYP3A4 inhibitors
PDE5 inhibitors (orthostatic hypotension)

Monitoring

Symptom response
BP
Mood

Reference: BNF; BAUS / EAU PE guidelines; SmPC; https://bnf.nice.org.uk/drugs/dapoxetine/. Verify against your local formulary and the latest BNF before prescribing.

Curated clinical cross-links plus same-class fallbacks.

Calculators

Pathways