Paediatrics
Neonatal Sepsis (Early + Late)
NICE NG195 — early-onset (<72h, GBS / E coli / Listeria) vs late-onset (>72h, CONS / Staph aureus / Gram-negatives), risk factor assessment, antibiotics within 1h.
Source: NICE NG195 (2021); BAPM
Step 1 of ~4
info
Recognise — Subtle Signs
Neonates rarely febrile; signs subtle and non-specific: temperature instability (low or high), poor feeding, vomiting, lethargy, irritability, mottling, apnoea, tachypnoea, grunting, hypoglycaemia, jaundice, seizures, bulging fontanelle. Maintain very low threshold. Verify all neonatal drug doses against a children's formulary.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Gentamicin (Paediatric) · Aminoglycoside — Neonatal Sepsis / Gram-Negative Infections in Children
- Colistin (Polymyxin E) · Polymyxin — Last-Resort MDR / Carbapenem-Resistant Gram-Negatives
- Fosfomycin · Phosphonic Acid Antibiotic — Uncomplicated UTI / ESBL / MDR Gram-Negatives
- Cefiderocol · Siderophore Cephalosporin (Pan-Drug Resistant Gram-Negatives)
- Andexanet Alfa (Ondexxya) · Factor Xa inhibitor reversal agent
- Prothrombin Complex Concentrate (PCC) · Coagulation Factor Concentrate — Warfarin Reversal
Decision support only. Always apply local guidelines and clinical judgement.