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Paediatric SIRS, Sepsis, and Septic Shock Criteria

Age-adjusted criteria for SIRS, sepsis, severe sepsis, and septic shock in children. Based on International Pediatric Sepsis Consensus Conference (IPSCC) 2005 definitions.

Used in: Sepsis

Score interpretation

SIRS Not Met / Low Risk 0–1

Insufficient criteria for SIRS -- reassess frequently

→ Monitor closely; serial observations; reassess for evolving sepsis; paediatric sepsis is dynamic -- repeat assessment in 1-2 hours; low threshold for reassessment in infants (< 3 months); document observations; senior review if clinical concern persists despite normal scoring.

SIRS / Sepsis -- Initiate Sepsis Pathway 2–3

SIRS criteria met with or without confirmed infection source

→ Initiate paediatric sepsis pathway (Sepsis 6 adapted for children); urgent bloods: FBC, CRP, PCT, blood cultures x2, lactate, U+E, LFTs, coag, blood gas; IV access (or IO if cannot gain IV within 2 attempts or < 90 seconds); IV/IO fluid bolus: 10-20 mL/kg 0.9% saline or Hartmann's over 5-15 minutes (repeat up to 40-60 mL/kg total, reassessing after each bolus); empirical antibiotics within 1 hour: ceftriaxone 50-80 mg/kg IV (max 2 g) or as per local policy; glucose -- avoid hypoglycaemia; notify paediatric senior within 30 minutes.

Severe Sepsis / Septic Shock -- Immediate PICU 4–9

Sepsis with organ dysfunction or haemodynamic compromise -- critical emergency

→ Immediate resuscitation team/PICU call; airway -- consider early intubation if tiring or GCS falling; fluid resuscitation: 10-20 mL/kg boluses, reassess after each, up to 40 mL/kg total -- stop if signs of fluid overload (new crackles, hepatomegaly, SpO2 falling); vasopressors if fluid-unresponsive: dopamine 5-20 mcg/kg/min or noradrenaline 0.1-2 mcg/kg/min (both via central or IO access); broad-spectrum antibiotics within 1 hour; glucose monitoring every 30 minutes; hydrocortisone 2 mg/kg IV (max 100 mg) if catecholamine-resistant; blood product support if coagulopathy; contact regional PICU transport team; document PELOD or pSOFA scores; family communication.

Interpretation bands for the Paediatric Sepsis Criteria. Apply clinical judgement and local guidance.

References

Related

Curated clinical cross-links plus same-class fallbacks.

Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.