ToxicologyEmergency
Carbon monoxide poisoning
Recognition, oxygen therapy and indications for hyperbaric oxygen in carbon monoxide poisoning.
Source: TOXBASE/NPIS; UHMS Hyperbaric Oxygen Indications 14th ed; BNF
Step 1 of ~6
action
Suspect CO and remove from source
Sources: faulty boilers/heaters, smoke inhalation, BBQs/generators in enclosed space, methylene chloride (paint stripper) metabolised to CO. Cluster of symptoms in same household → think CO.
Features: headache, nausea, dizziness, confusion, chest pain, syncope, seizures, coma. Cherry-red skin is uncommon and late. SpO₂ pulse oximeter is FALSELY NORMAL (does not distinguish HbCO from HbO₂) — must use co-oximeter.
ABCDE; remove from source; high-flow oxygen via non-rebreather mask 15 L/min immediately (do not wait for level).
Bloods: VBG/ABG including HbCO (co-oximetry), lactate, glucose, troponin, paracetamol/salicylate, U&E, ECG. Pregnancy test in women of reproductive age.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Dapsone · Anti-inflammatory / Antimicrobial
- Magnesium Sulphate IV (Additional Indications) · Magnesium salt / bronchodilator / antiarrhythmic
- Estradiol (HRT — Hormone Replacement Therapy) · Oestrogen Replacement Therapy
- Clarithromycin (ENT Indications) · Macrolide antibiotic
- Allopurinol · Xanthine Oxidase Inhibitor — Urate-lowering Therapy
- Febuxostat · Xanthine Oxidase Inhibitor — Urate-lowering Therapy
Pathways
- Paracetamol overdose · TOXBASE/NPIS; MHRA DSU 2012/2024; SNAP regimen (Lancet 2014); BNF
- TCA overdose · TOXBASE/NPIS; AACT/EAPCCT position statements; Resuscitation Council UK ALS
- Opioid overdose · TOXBASE/NPIS; Resuscitation Council UK; BNF
- Anticholinergic toxidrome · TOXBASE/NPIS; AACT/EAPCCT; BNF
- Benzodiazepine overdose · TOXBASE/NPIS; AACT/EAPCCT; BNF
- β-blocker overdose · TOXBASE/NPIS; AACT/EAPCCT; ESC; BNF
Decision support only. Always apply local guidelines and clinical judgement.