Renal A
Urine Protein:Creatinine Ratio (UPCR)
Spot urine protein:creatinine ratio estimates 24-hour urinary protein excretion without timed urine collection.
Score interpretation
A1 — normal to mildly increased (PCR < 15 mg/mmol)
→ Normal; no action required
A2 — moderately increased proteinuria (PCR 15–50 mg/mmol)
→ CKD monitoring; start RAAS inhibitor if diabetic; annual review
A3 — severely increased proteinuria (PCR > 50 mg/mmol)
→ RAAS inhibitor; nephrology referral; investigate cause (GN, diabetic nephropathy)
Nephrotic range proteinuria (>350 mg/mmol)
→ Urgent nephrology; renal biopsy consideration; oedema management; VTE prophylaxis
Interpretation bands for the UPCR. Apply clinical judgement and local guidance.
References
- KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl. 2013;3(1):1-150.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- AIR Score for Appendicitis · Diagnostic
- Spontaneous Bacterial Peritonitis (SBP) Diagnosis · Diagnostic
- Alvarado Score (MANTRELS) for Appendicitis · Diagnostic
- New Orleans Head CT Decision Rule · Diagnostic
- MS Phenotype Classification (McDonald / Phenotype) · Diagnostic
- CHALICE Rule for Childhood Head Injury · Diagnostic
Drugs
- Telitacicept (APRIL/BLyS Dual Inhibitor — SLE/IgA Nephropathy) · TACI-Fc Fusion Protein (Dual APRIL and BLyS Inhibitor)
- Dairy products · Nutritional source (calcium, protein, vitamin D)
- Protein C (Specialist drug) · Recombinant/plasma-derived protein C concentrate
- Respiratory syncytial virus (RSV) vaccine · RSV pre-fusion F protein vaccine
- Tuberculin purified protein derivative · Mycobacterial antigen for delayed-type hypersensitivity testing
- Fluorescein Sodium 2% Eye Drops · Diagnostic ophthalmic dye
Pathways
- Hyperkalaemia Management · UK Kidney Association Guidelines 2020; NICE CKD Guidelines
- Rhabdomyolysis · Renal Association 2018; UpToDate 2024
- Hypocalcaemia (Adult) · Society for Endocrinology
- SIADH (Endocrine Perspective) · European Hyponatraemia Guidelines 2014
- Hepatorenal Syndrome · EASL 2018; ICA 2015
- Acute Kidney Injury (AKI) · KDIGO 2012 / NICE AKI 2019
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.