Local anaesthetic with vasoconstrictor
Adrenaline with articaine hydrochloride
Brand names: Septanest
Adult dose
Dose: Articaine 4% with adrenaline 1:100,000 or 1:200,000; max 7 mg/kg articaine
Route: Submucosal/Infiltration
Frequency: Single-shot
Clinical pearls
- Common dental LA; aspirate before injection
- Avoid IV
Contraindications
- Severe cardiac conduction disorders
- Untreated hyperthyroidism
- Phaeochromocytoma
Side effects
- Tachycardia
- Hypertension
- Methaemoglobinaemia (rare)
Interactions
- Non-selective beta-blockers
- TCAs, MAOIs
Monitoring
- HR/BP
- Symptoms
Reference: BNF; AAGBI Safety Guideline – Local Anaesthetic Toxicity 2010; SmPC Septanest. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators