ToxicologyEmergencyAnaesthesia
Propofol / ketamine toxicity
Acute sedation, propofol infusion syndrome (PRIS) and ketamine recreational use — including urological complications.
Source: TOXBASE/NPIS; AAGBI; AACT/EAPCCT; BNF
Step 1 of ~7
action
Identify agent and pattern
Two distinct presentations:
1. Propofol — rare overdose (mostly iatrogenic over-sedation, induction-related hypotension/apnoea, or PRIS in prolonged ITU sedation).
2. Ketamine — recreational dissociative use; iatrogenic over-sedation; chronic abuse causes urological/biliary disease.
ABCDE; bloods: VBG, glucose, U&E, LFTs, CK (rhabdo), lactate, lipase (PRIS), triglycerides (PRIS), paracetamol/salicylate, ECG (Brugada-like in PRIS).
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
Same class
Pathways
- Paracetamol overdose · TOXBASE/NPIS; MHRA DSU 2012/2024; SNAP regimen (Lancet 2014); BNF
- TCA overdose · TOXBASE/NPIS; AACT/EAPCCT position statements; Resuscitation Council UK ALS
- Opioid overdose · TOXBASE/NPIS; Resuscitation Council UK; BNF
- Anticholinergic toxidrome · TOXBASE/NPIS; AACT/EAPCCT; BNF
- Benzodiazepine overdose · TOXBASE/NPIS; AACT/EAPCCT; BNF
- β-blocker overdose · TOXBASE/NPIS; AACT/EAPCCT; ESC; BNF
Decision support only. Always apply local guidelines and clinical judgement.