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Transthyretin (TTR) stabiliser

Acoramidis

Brand names: Beyonttra

Adult dose

Dose: 800 mg BD (per SmPC)
Route: Oral
Frequency: Twice daily

Clinical pearls

  • Wild-type or hereditary ATTR cardiomyopathy; specialist initiation; may displace thyroxine and lower TTR levels

Contraindications

  • Hypersensitivity

Side effects

  • Diarrhoea
  • Abdominal pain
  • Reduced thyroxine-binding (interpret thyroid tests with care)

Interactions

  • Limited; refer to SmPC

Monitoring

  • NT-proBNP, NYHA class
  • TFTs interpretation

Reference: BNF; ESC HF 2023 update; SmPC Beyonttra. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.