ACE inhibitor + dihydropyridine CCB
Perindopril erbumine with amlodipine
Brand names: Coveram
Adult dose
Dose: 4/5mg, 4/10mg, 8/5mg or 8/10mg PO OD
Route: PO
Frequency: OD
Clinical pearls
- Hypertension when monotherapy inadequate
- ACCOMPLISH-style combination preferred over ACEi+thiazide
Contraindications
- Pregnancy
- Severe hypotension
- Cardiogenic shock
- Severe aortic stenosis
Side effects
- Cough
- Peripheral oedema
- Headache
- Hypotension
- Hyperkalaemia
Interactions
- NSAIDs
- Strong CYP3A4 modulators
- Simvastatin (limit 20mg)
- Lithium
Monitoring
- U&E
- BP
Reference: BNF; NICE NG136; https://bnf.nice.org.uk/drugs/perindopril-erbumine-with-amlodipine/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- SMART Risk Score for Recurrent CVD · Cardiovascular Risk
- PCSK9 Inhibitor Eligibility Assessment · Lipid Management
- Immune-Related Adverse Events (irAE) -- GI Toxicity Colitis Grading · Oncology-Related GI
- irAE Hepatitis Grading (CTCAE) · Immunotherapy
- DIPSS — Dynamic International Prognostic Scoring System for Myelofibrosis · Cancer Prognosis
- BALL Score for Relapsed/Refractory CLL · Leukaemia
Pathways
- Acute Heart Failure · ESC 2021 Heart Failure Guidelines; NICE NG106
- NSTEMI / Unstable Angina · ESC 2020 NSTEMI Guidelines; NICE NG185
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines