Hydrocortisone (Topical)
Brand names: Hc45, Dioderm
Topical hydrocortisone is a mild corticosteroid applied to the skin for mild inflammatory dermatoses such as eczema, dermatitis and insect-bite reactions.
Adult dose
Dose auto-extracted from UK Summary of Product Characteristics (SPC) via the eMC; US FDA prescribing information (openFDA / DailyMed) — cross-check; US labelling may differ from UK — not yet clinician-verified. Always confirm against the product SmPC and your local formulary before prescribing.
Contraindications
- Bacterial (e.g. impetigo), viral (e.g. Herpes simplex) or fungal (e.g. candidal or dermatophyte) skin infections
- Hypersensitivity to the active substance or to any of the excipients
- Use on the eyes and face
- Use in the ano-genital region
- Broken or infected skin, including cold sores, acne and athlete's foot
Side effects
- Hypersensitivity reactions — application should stop immediately if any signs appear
- Striae, especially in intertriginous areas
- Withdrawal reactions (frequency not known): redness of the skin which may extend beyond the initially affected area
- Withdrawal reactions: burning or stinging sensation, itch
- Withdrawal reactions: skin peeling, oozing pustules
- Excipients: chlorocresol may cause allergic reactions; cetostearyl alcohol may cause local skin reactions (e.g. contact dermatitis)
Interactions
- None known (§4.5)
Clinical monograph
How it works
It activates glucocorticoid receptors in skin cells to reduce inflammatory mediator release, producing local anti-inflammatory and antipruritic effects.
Prescribing in practice
- Although low potency, avoid prolonged use on the face and flexures and limit application in infants, as even mild steroids can cause local skin thinning with excessive use.
- Do not apply to untreated infected skin, acne or rosacea.
- Some low-strength preparations are available for short-term use over the counter for limited indications and body sites.
Monitoring
Review response after a short course and reassess if the rash fails to settle or appears infected.
Counselling the patient
- Apply a thin layer to affected areas, typically once or twice daily, for a short period.
- Avoid the eyes and only use on the face if specifically advised.
- Keep using emollients alongside to maintain the skin barrier.
Evidence & guidelines
Mild topical corticosteroids such as hydrocortisone are first-line for mild eczema flares in line with NICE eczema guidance.
Reference: NICE NG190 Atopic Eczema; British Association of Dermatology (BAD) Guidelines; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. The structured dose values shown have been reviewed by a clinician. Monograph status: clinician-reviewed (2026-07-04).
Related
Curated clinical cross-links plus same-class fallbacks.
- Suspicious Pigmented Lesion — Melanoma Pathway · NICE NG14 2015 / BAD
- Cellulitis and Erysipelas · NICE NG141 2019 / CREST
- Psoriasis — Severity Assessment and Step-Up Therapy · NICE NG153 2019 / BAD
- Atopic Eczema — Assessment and Step-Up Therapy · NICE NG95 2023
- Urticaria and Angioedema · BSACI / EAACI Guidelines 2022
- Acne Vulgaris — Grading and Treatment · NICE NG198 2021 / BAD