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Mild Topical Corticosteroid Pregnancy: Inadequate evidence of safety in human pregnancy; topical corticosteroids in pregnant animals can cause abnormalities of foetal development (cleft palate, intra-uterine growth retardation), so a very small risk in the human foetus cannot be excluded. Breastfeeding: no evidence against use in lactating women, but exercise caution and do not apply to the chest area

Hydrocortisone (Topical)

Brand names: Hc45, Dioderm

Used in: Anaphylaxis & Allergy

Topical hydrocortisone is a mild corticosteroid applied to the skin for mild inflammatory dermatoses such as eczema, dermatitis and insect-bite reactions.

Auto-extracted from the source labelling — not yet independently clinician-verified. These values were distilled from the UK SPC (or the US label where noted) but have not had a clinician sign-off. Confirm against the current SmPC before prescribing.

Adult dose

Dose: Apply sparingly over a small area
Route: Cutaneous (topical cream 1% w/w)
Frequency: Once or twice a day
Max: Maximum treatment period of one week
Source: eMC SPC for Hydrocortisone 1% w/w Cream, §4.2. Use sparingly over a small area once/twice a day for a maximum period of one week; if the condition has not improved, or worsens, the patient should consult their doctor. PAEDIATRIC: the SPC states this product should not be recommended for use on children under 10 years of age without medical advice, and no per-kg or age-banded paediatric dose is given. §4.4 adds that although topical corticosteroids are generally regarded as safe even for long-term administration in adults, there is potential for overdosage in infants and children; extreme caution is required in dermatoses of infancy, especially napkin eruption where the napkin can act as an occlusive dressing and increase absorption, and in infants and children courses of treatment should not normally exceed 7 days. Verify paediatric use against a children's formulary. Do not use under an occlusive dressing. Prolonged application to the face is undesirable. Appropriate antimicrobial therapy should be used whenever treating inflammatory lesions that have become infected; any spread of infection requires withdrawal of the topical corticosteroid and systemic antimicrobial treatment. Topical steroid withdrawal syndrome: long-term use can cause rebound flares after stopping — suspect a withdrawal reaction if the condition recurs within days to weeks of successful treatment; reapply with caution and consider specialist advice or alternative treatment. Labelled as a mild steroid. The bundle also contains a US OTC hydrocortisone 'anti itch' label (apply not more than 3 to 4 times daily; do not use under 2 years) — not used, as the UK SPC is preferred and specifies once/twice daily.

Dose auto-extracted from UK Summary of Product Characteristics (SPC) via the eMC; US FDA prescribing information (openFDA / DailyMed) — cross-check; US labelling may differ from UK — not yet clinician-verified. Always confirm against the product SmPC and your local formulary before prescribing.

Contraindications

  • Bacterial (e.g. impetigo), viral (e.g. Herpes simplex) or fungal (e.g. candidal or dermatophyte) skin infections
  • Hypersensitivity to the active substance or to any of the excipients
  • Use on the eyes and face
  • Use in the ano-genital region
  • Broken or infected skin, including cold sores, acne and athlete's foot

Side effects

  • Hypersensitivity reactions — application should stop immediately if any signs appear
  • Striae, especially in intertriginous areas
  • Withdrawal reactions (frequency not known): redness of the skin which may extend beyond the initially affected area
  • Withdrawal reactions: burning or stinging sensation, itch
  • Withdrawal reactions: skin peeling, oozing pustules
  • Excipients: chlorocresol may cause allergic reactions; cetostearyl alcohol may cause local skin reactions (e.g. contact dermatitis)

Interactions

  • None known (§4.5)

Clinical monograph

How it works

It activates glucocorticoid receptors in skin cells to reduce inflammatory mediator release, producing local anti-inflammatory and antipruritic effects.

Prescribing in practice

  • Although low potency, avoid prolonged use on the face and flexures and limit application in infants, as even mild steroids can cause local skin thinning with excessive use.
  • Do not apply to untreated infected skin, acne or rosacea.
  • Some low-strength preparations are available for short-term use over the counter for limited indications and body sites.

Monitoring

Review response after a short course and reassess if the rash fails to settle or appears infected.

Counselling the patient

  • Apply a thin layer to affected areas, typically once or twice daily, for a short period.
  • Avoid the eyes and only use on the face if specifically advised.
  • Keep using emollients alongside to maintain the skin barrier.

Evidence & guidelines

Mild topical corticosteroids such as hydrocortisone are first-line for mild eczema flares in line with NICE eczema guidance.

Reference: NICE NG190 Atopic Eczema; British Association of Dermatology (BAD) Guidelines; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. The structured dose values shown have been reviewed by a clinician. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.