Lille Model for Alcoholic Hepatitis
Assesses response to corticosteroid therapy in severe alcoholic hepatitis at Day 7. Lille score > 0.45 predicts non-response — steroids should be stopped.
Score interpretation
Lille ≤ 0.16: Complete steroid responder. ~91% 6-month survival.
→ Continue prednisolone 40mg OD to complete 28-day course. Then taper over 2–4 weeks. Abstinence support, nutrition, thiamine.
Lille 0.16–0.45: Partial responder. ~79% 6-month survival.
→ Continue prednisolone to complete 28-day course. Reassess. Liver unit referral. Alcohol support services.
Lille > 0.45: Non-responder. ~25% 6-month survival. Continued steroids offer no benefit.
→ Stop prednisolone immediately. Consider pentoxifylline (limited evidence). Liver transplant assessment if abstinent period met. Palliative care discussion. N-acetylcysteine as supportive agent.
Interpretation bands for the Lille Score. Apply clinical judgement and local guidance.
References
- Louvet A, et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology. 2007;45(6):1348–1354.
Related
Curated clinical cross-links plus same-class fallbacks.
- Prednisolone (Systemic) · Systemic Corticosteroid — Acute Dermatoses
- Prednisolone (Systemic) · Systemic Corticosteroid
- Prednisolone (Sudden Sensorineural Hearing Loss) · Corticosteroid (systemic — SSNHL treatment)
- Prednisolone (Oral — Nasal Polyp Reduction) · Systemic Corticosteroid
- Prednisolone (Oral — General Medicine) · Oral Corticosteroid
- Prednisolone (IBD / GI Use) · Systemic Corticosteroid
- Upper GI Bleeding · BSG Guidelines 2019; NICE NG141
- Lower Gastrointestinal Bleed · NICE; BSG; ACPGBI — Commissioning Guide
- Acute Pancreatitis · NICE; IAP/APA; ACPGBI — CG104
- Sepsis Screening and Sepsis Six · UK Sepsis Trust; NICE NG51; Surviving Sepsis Campaign 2021
- Unintentional Weight Loss Workup · NICE NG12; BSG
- Chronic Fatigue Workup · NICE NG206; BMJ Best Practice
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.