Recombinant C1 esterase inhibitor
Conestat alfa
Brand names: Ruconest
Adult dose
Dose: 50 units/kg IV (max 4200 units = 2 vials) — slow IV infusion over 5 minutes
Route: IV
Frequency: per attack
Clinical pearls
- Acute hereditary angioedema attacks in adults and adolescents
- Refrigerate; reconstitute carefully
Contraindications
- Rabbit allergy
Side effects
- Headache
- Nausea
- Hypersensitivity (rabbit-derived)
Reference: BNF; https://bnf.nice.org.uk/drugs/conestat-alfa/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- SMART Risk Score for Recurrent CVD · Cardiovascular Risk
- PCSK9 Inhibitor Eligibility Assessment · Lipid Management
- Immune-Related Adverse Events (irAE) -- GI Toxicity Colitis Grading · Oncology-Related GI
- irAE Hepatitis Grading (CTCAE) · Immunotherapy
- DIPSS — Dynamic International Prognostic Scoring System for Myelofibrosis · Cancer Prognosis
- BALL Score for Relapsed/Refractory CLL · Leukaemia
Pathways
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines
- Syncope Assessment · ESC 2018 Syncope Guidelines; NICE NG109
- Acute Chest Pain · NICE CG95; ESC 2023 ACS Guidelines