Allergen immunotherapy
Grass pollen extracts
Brand names: Grazax (sublingual), Pollinex (SC)
Adult dose
Dose: Sublingual (Grazax): 1 tab daily, start 4 months before pollen season, continue for 3 years. SC: per up-titration schedule
Route: SL/SC
Frequency: OD or per regimen
Clinical pearls
- First sublingual dose under medical supervision; anaphylaxis kit on hand for SC therapy
- BSACI specialist referral
Contraindications
- Severe/uncontrolled asthma
- Active malignancy
- Severe immune deficiency
- Recent oral inflammation/dental procedure (sublingual)
Side effects
- Local oral itch/oedema
- Anaphylaxis (rare; SC route higher risk)
Interactions
- β-blockers (worsen anaphylaxis)
Reference: BNF; BSACI immunotherapy guidelines; https://bnf.nice.org.uk/drugs/grass-pollen-extracts/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Pathways
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines
- Syncope Assessment · ESC 2018 Syncope Guidelines; NICE NG109
- Acute Chest Pain · NICE CG95; ESC 2023 ACS Guidelines