Bradykinin B2 receptor antagonist
Icatibant
Brand names: Firazyr
Adult dose
Dose: 30mg SC; may repeat every 6h up to 3 doses/24h
Route: SC
Frequency: per attack
Clinical pearls
- Acute attacks of hereditary angioedema (C1-INH deficiency) in adults and adolescents ≥2y
- Self-administration after training
Contraindications
- Acute coronary syndrome (caution — may worsen ischaemia)
- Recent stroke
Side effects
- Injection site reactions (very common)
- Dizziness
- Pyrexia
Interactions
- ACE inhibitors (theoretical antagonism)
Reference: BNF; NICE TA484; SmPC; https://bnf.nice.org.uk/drugs/icatibant/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines
- Syncope Assessment · ESC 2018 Syncope Guidelines; NICE NG109
- Acute Chest Pain · NICE CG95; ESC 2023 ACS Guidelines