Amide LA + vasopressin analogue
Prilocaine with felypressin
Brand names: Citanest with Octapressin
Adult dose
Dose: Max 8 mg/kg prilocaine; total max 400mg
Route: Infiltration
Frequency: single
Clinical pearls
- Dental anaesthesia where adrenaline contraindicated
- Felypressin = synthetic vasopressin (Octapressin)
Contraindications
- Hypersensitivity
- Methaemoglobinaemia
- Severe heart block
- Pregnancy (vasopressin caution)
Side effects
- Methaemoglobinaemia
- Vasoconstrictor effects (less than adrenaline)
- CNS toxicity
Interactions
- Sympathomimetics
Reference: BNF; https://bnf.nice.org.uk/drugs/prilocaine-with-felypressin/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.