Benzydamine hydrochloride

How it works

It is a non-steroidal agent with local analgesic and anti-inflammatory effects, and also exerts a local anaesthetic and mild antiseptic action on inflamed mucosa.

Prescribing in practice

• It is for local oropharyngeal use only and patients should be advised that stinging or numbness of the mouth may occur on application.
• The mouthwash may be diluted with water if it causes stinging, particularly in ulcerated mucosa.
• It is useful for mucositis-related pain but provides symptomatic relief rather than treating the underlying cause.

Monitoring

No specific monitoring is required; assess symptomatic relief and local tolerability.

Counselling the patient

• Use the mouthwash or spray for symptom relief and do not swallow large amounts.
• Dilute the mouthwash with water if it stings.
• Seek advice if mouth or throat symptoms persist.

Evidence & guidelines

Topical benzydamine is a recognised option for symptomatic relief of oral mucositis and oropharyngeal inflammation.