Topical otic steroid + antibiotic combination
Hydrocortisone with neomycin and polymyxin B
Brand names: Otosporin
Adult dose
Dose: 3 drops in affected ear TDS–QDS for ≤7 days
Route: Topical (otic)
Frequency: TDS-QDS
Clinical pearls
- Acute otitis externa with intact tympanic membrane
Contraindications
- Perforated tympanic membrane
- Viral/fungal otitis externa
Side effects
- Local irritation
- Ototoxicity if applied through perforation
- Sensitisation to neomycin
Reference: BNF; https://bnf.nice.org.uk/drugs/hydrocortisone-with-neomycin-and-polymyxin-b-sulfate/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Steroid Dose Equivalence · Medications
- Adrenal Insufficiency Assessment · Adrenal
- Adrenal Crisis Risk Score · Adrenal Disorders
- Centor / McIsaac Score for Strep Pharyngitis · Throat
- Lille Model (Steroid Response in Alcoholic Hepatitis) · Alcoholic Liver Disease
- Ho Index for Predicting Response to Medical Therapy in IBD · Inflammatory Bowel Disease
Pathways
- Adult Upper Airway Obstruction (Stridor) · DAS 2015 unanticipated difficult airway; RCEM
- Epistaxis Management · ENT-UK / NICE
- Acute Otitis Media · NICE NG91 2018
- Tonsillitis and Sore Throat · NICE NG84 2018
- Benign Paroxysmal Positional Vertigo · NICE CG124 / AAO-HNS Guidelines
- Acute Rhinosinusitis · NICE NG79 2017 / EPOS 2020